The aim was to evaluate the effectiveness of the longterm administration of intranasal calcitonin spray for the treatment of central giant cell granuloma cgcg in a retrospective case study. The case reported here resembled a wide variety of conditions that led to a misdiagnosis both on clinical and radiographic examinations but was. A recurrent central giant cell granuloma in a young patient. Cgcg is the most common giant cell lesion of the jaws. Central giant cell granuloma is an uncommon, benign, and proliferative lesion whose etiology is not defined. It occurs most commonly in mandible, but can also occur in maxilla. We present a child with symptoms of rickets as the first clinical sign of a central giant cell granuloma cgcg with high serum levels of fgf23, a hormone associated with decreased phosphate resorption. Tumorinduced rickets in a child with a central giant cell. Central giant cell granuloma is a benign intraosseous lesion. Achieving the correct diagnosis is reportedly difficult because cgcgs are very similar to odontogenic jaw tumors. A case report elisa fernandezcooke, md a, jaime cruzrojo, md, carmen gallego, mdb, ana isabel romance, mdc, rocio mosquedapena, md, yolanda almaden, mdd, jaime sanchez del pozo, mda abstract tumorinduced osteomalaciarickets is a rare paraneoplastic disorder. Central giant cell granuloma cgcg at operation, intraorally, lesion was defined by who1,4 and described by extended superoinferiorly from the lower 1. Central giant cell granuloma of the maxilla bmj case reports.
Central giant cell granulomas are benign tumours of the mandible, presenting in children. An aggressive central giant cell granuloma in a pediatric. Pdf agressive central giant cell granuloma of the mandible. This lesion is more common in border of mandible to the upper one third of gaertner. Central giant cell granuloma a case report balaji p. The case presented in this article occurrence of central giant cell granuloma of the confirms to reported site, age, sex and jaw.
It accounts for 7% benign maxillary tumors, and females are predominantly affected in 23ofcases before age 20years 1. We herein describe an intriguing case of a 21yearold male patient who. We report a case of large temporal giant cell reparative granuloma in a 72yearold man. We present a case of an aggressive central giant cell granuloma cgcg in a six yearold female. Case report central giant cell granuloma of posterior. Central giant cell granuloma cgcg is an uncommon benign bony lesion that occurs in the mandible and maxilla. Mr imaging depicted a right temporal expansile multiloculated lesion, with hyper and hypointense signal areas on t2weighted images, heterogeneously enhancing after gadolinium administration. Central giant cell granuloma cgcg is a rare, nonneoplastic, benign lesion that exhibits expansive and osteolytic biological behavior.
The condition was first identified in 1953 by jaffe, who initially termed this lesion as a central giant cell reparative granuloma, but nowadays the reparative word has been. A central giant cell granuloma in posterior part of maxillaa. Central giant cell granuloma was 1st described in jaws by jaffe 1953. Giant cell central granuloma gccg is an uncommon pseudotumor of the maxilla. Pdf central giant cell granuloma of the posterior maxilla. Surgical treatment and reconstruction for central giant. The affected patient was a 25 year old iraqi male who reported to us with recurrent pericoronitis in relation to lower left third molar. Intralesional corticosteroid injection for central giant cell granuloma. S dental college, hospital and research centre, greater noida, india 2 army dental core, central government of india, india 3 department of oral medicine and radiology, i. The central giant cell granuloma is often found in the mandible commonly occurring in patients under.
Central giant cell granuloma condyle mandible intraosseous abstract introduction. Central giant cell granuloma of the mandible american. Peripheral giant cell granuloma or so called giant cell epulis is the most common oral giant cell lesion. Central giant cell granuloma cgcg is an uncommon benign intraosseous lesion of the jaw, found predominantly in children and young adults below 30 years of age. Divided into non and aggressive subtypes, the aggressive subtype is relatively rare and can occasionally progress rapidly, resulting in significant morbidity. Belonging to the group of giant and cystic cell lesions of the 4th edition of the head and neck tumours classification by who, the central giant cell gran uloma is an intraosseous osteolytic lesion, with an unknown etiology, characterized by a benign pro liferation of fibroblasts and osteoclastlike giant cells, within a well vascularized stroma. Thought to represent a reparative response to intrabony haemorrhage and inflammation, cgcg was once regarded as a reactive lesion. Central giant cell granuloma cgcg is a rare, nonneoplastic, benign lesion that exhibits expansive. Extremely aggressive behavior of central giant cell. Surgical treatment and reconstruction for central giant cell.
The purpose of this article is to report the clinical case of a 14yearold girl with a mandibular central giant cell granuloma cgcg, which was favorably treated with intralesional. Central giant cell granuloma cgcg is an uncommon, benign, and proliferative lesion of the jaw with an unknown etiology. Central giant cell granuloma cgcg of the jaws is a benign, intraosseous, osteolytic lesion of debatable etiology. Correlating all clinical features and all investigation we finally diagnosed this case as central giant cell granuloma. Radiologically, it is usually a welldefined radiolucent defect with hazy opacity, classically described. First expression of primary hyperparathyroidism deepanshugulati, 1 vishalbansal, 1 prajeshdubey, 1 sanjaypandey, 2 andabhinavagrawal 3 department of oral and maxillofacial surgery, subharti dental college, meerut. Central giant cell granuloma is a benign, aggressive neoplasm composed of multinucleated giant cells that almost exclusively occurs in the. Pdf this article describes a case of central giant cell granuloma in the right posterior region of the mandible in a 10 yearold boy. It was first described as central giant cell reparative granuloma by jaffe h l in the year 1953. Jul 18, 2019 central giant cell granulomas are benign tumours of the mandible, presenting in children and young adults. The case reported here resembled a wide variety of conditions that led to a misdiagnosis both on clinical and radiographic examinations but was histopathologically diagnosed as cgcg. Although central giant cell granulomas cgcgs appear to be benign, their radiographic findings are active. A case report with diagnostic dilemma garima singh 1, ashish thakur 2, heena sadiq 1, priti gupta 3 1 department of oral and maxillofacial pathology, i.
Central giant cell granuloma is a benign intraosseous lesion of the jaws. Central giant cell granulomas of the condyle are rare. Case report open access an aggressive central giant cell granuloma in a pediatric patient. Multifocal central giant cell lesions of the maxillofacial skeleton. Rebello,1,mggtorres1,vburgos1,coliveira1,jndossantos2,raazevedo1 andpsfcampos1 1department of oral and maxillofacial radiology, federal university of bahia, school of dentistry, salvador, ba, brazil. Tumorinduced osteomalaciarickets is a rare paraneoplastic disorder associated with a tumorproducing fibroblast growth factor 23 fgf23. A central giant cell granuloma in posterior part of. The case described here involved maxilla which was treated with surgical excision. Mar 21, 2012 central giant cell granuloma formerly called as giant cell reparative granuloma is a non neoplastic proliferative lesion of unknown etiology. Cgcg lacks in clinical and radiographical pathognomonic features to distinguish from common lesions occurring in this region. It is twice as common in females and is more likely to occur before age 30. Radiologic features, including those seen with computed tomography, of central giant cell granuloma of the jaws. For the previously reported cases in one female and three males, the mean age at presentation was 30 years. Central giant cell granuloma formerly called as giant cell reparative granuloma is a non neoplastic proliferative lesion of unknown etiology.
The lesion was removed by curettage and a histopathological examination was carried out. Central giantcell granuloma cgcg is a localised benign condition of the jaws. Central giant cell granuloma cgcg is a relatively uncommon benign bony lesion of a variably aggressive nature. To the best of our knowledge, the present case is the first report of recurrent cgcg of the nasal cavity and sinuses and its. Radiotherapy for recurrent central giant cell granuloma. Giant cell granuloma gcg is an uncommon, benign, proliferative, intraosseous lesion representing granuloma. Central giant cell granuloma cgcg is a relatively uncommon benign bony lesion of a variably aggressive nature, accounting for less than 7% of all benign jaw lesions. Central giant cell granulomas are benign tumours of the mandible, presenting in children and young adults. This article describes a case of central giant cell granuloma in the right posterior region of the mandible in a 10 yearold boy. Dec 28, 2019 central giant cell granulomas of the condyle are rare.
Giant cell granuloma gcg is an uncommon, benign, proliferative, intraosseous lesion representing gran uloma is an intraosseous osteolytic lesion, with an unknown etiology, characterized by a benign pro liferation of fibroblasts and osteoclastlike giant cells, within a well vascularized stroma. Central giant cell granuloma and fibrous dysplasia. Central giant cell granuloma of the posterior maxilla. Case report open access radiotherapy for recurrent central giant cell granuloma. Central giant cell granuloma cgcg is a benign intraosseous lesion that occurs in long bones. The lesion principally affects the mandible and maxilla and rarely affects the skull or small bones of the hands and feet 2, 3. It is actually an asymptomatic lesion which becomes evident during routine radiographic examination or as a result of painless but visible. Central giant cell granuloma of the mandibular condyle. Pdf central giant cell granuloma cgcg is a benign intraosseous lesion of unknown etiology, and occurs in jaws. The reported case is nonaggressive central giant cell granuloma of posterior mandible.
Case report central giant cell granuloma of posterior maxilla. Multifocal central giant cell granuloma a case report article pdf available in iranian journal of pathology 1. To the best of our knowledge, the present case is the first report of. Central giant cell granuloma cgcg is a benign intraosseous lesion of the jaws that is found predominantly in children and young adults. Tumorinduced rickets in a child with a central giant cell granuloma.
Casereport munzenmayer j1, tapia p 2, zeballos j, martinez a 3, compan a4, urra a 5, spencer ml6 summary this case report describes a 19yearold female patient with a central giant cell granuloma in the left mandibular condyle, treated with en bloc resection. It is considered widely to be a nonneoplastic lesion although formerly designated as. Intralesional corticosteroid injection for central giant. Central giantcell granulomas are more common in the anterior mandible, often crossing the midline and causing painless swellings. Birgit kruselosler, raihanatou diallo, christoph jaffe2 in 1953. These tumors become severely invasive with the stimulus of surgery, resembling malignant tumors. It is actually an asymptomatic lesion which becomes evident during routine radiographic examination or as a result of painless but visible expansion of. Extra oral examination revealed a diffuse swelling on the left side of face causing slight obliteration of nasio. Fibrous dysplasia is a benign fibroosseous lesion arising in an intramedullary location. Jul 19, 2019 central giant cell granuloma cgcg is a rare, nonneoplastic, benign lesion that exhibits expansive and osteolytic biological behavior. Intralesional corticosteroid injection for central giant cell. Peripheral giant cell granuloma is a common benign and reactive gingival epulis in oral cavity. It is also known as giant cell epulis, osteoclastoma, giant cell reparative granuloma or giant cell hyperplasia. Central giant cell granuloma cgcg, formerly called giant cell reparative granuloma, is a nonneoplastic proliferative lesion of an unknown aetiology.
Pdf multifocal central giant cell granuloma a case report. It is an uncommon tumor in jaws, its etiology and pathogenesis is unknown. Central giant cell granuloma a case report balaji p, balaji. It usually presents as a purplishred soft tissue nodule consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells. It is often difficult to make a clinical diagnosis. Multifocal central giant cell granuloma a case report ncbi. We present the case of a 60yearold woman with preauricular swelling, limitation of joint motion and pain on only the right side. Jul 20, 20 central giant cell granuloma cgcg is a relatively uncommon benign bony lesion of a variably aggressive nature, accounting for less than 7% of all benign jaw lesions.